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Inheritance · Paper 2 — Free Biology HL Practice Questions

1MasterySAQ-SPunnett squares and genetic ratios6 marksPaper 2~9 min
In a species of fruit fly (Drosophila melanogaster), grey body colour (GG) is dominant over black body colour (gg). A female fly heterozygous for body colour is crossed with a male fly that has a black body. In a large experiment, 800 offspring are produced: 560 have grey bodies and 240 have black bodies.
(a)
State the expected phenotypic ratio and the expected percentage of black-bodied offspring from this cross. [2 marks]
(b)
Explain how meiotic drive in the female parent could account for a deviation from the expected ratio. [2 marks]
(c)
Using the experimental data, evaluate whether the results are consistent with meiotic drive acting on the GG allele in the female parent. [2 marks]
diagram

Solutions

2ChallengeSAQ-LMendelian inheritance9 marksPaper 2~14 min
A genetic counsellor analyses a family pedigree for a rare autosomal recessive disorder controlled by a single gene (alleles DD and dd). The disorder causes severe metabolic dysfunction and is often fatal in early childhood. An affected individual (genotype dddd) has two unaffected parents. The affected individual marries an unaffected woman with no known family history of the disorder.
(a)
State the genotypes of the affected individual's parents. [1 mark]
(b)
The recessive allele frequency in the general population is q=0.02q = 0.02 and the population is in Hardy–Weinberg equilibrium, where p2+2pq+q2=1p^2 + 2pq + q^2 = 1. Calculate the probability that the unaffected woman is a carrier (heterozygous DdDd). [3 marks]
(c)
Explain how the Law of Segregation accounts for the production of the dddd child from two heterozygous parents. [2 marks]
(d)
Evaluate the use of population-wide genetic screening to identify carriers of this disorder prior to reproduction. [3 marks]
diagram

Solutions

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