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Cell Division: Mitosis and Meiosis — Free MYP5 Biology Practice Questions
1QuestionCell Cycle and MitosisConcept Practice
3 marks~5 minCriterion A
The diagram below shows a cell during mitosis in which all chromosomes are aligned at the cell's equatorial plane, with spindle fibres from opposite poles attached to the centromere of each chromosome.
a
Identify the phase of mitosis shown in the diagram. [1]
b
Explain how the attachment of spindle fibres to chromosomes during this phase ensures that sister chromatids are distributed equally between the two daughter cells. [2]
Solutions
2QuestionCell Cycle and MitosisAssessment Practice
2 marks~3 minCriterion C
The diagram shows a cell at four stages of mitosis.
a
Identify one key event occurring during metaphase, using appropriate biological terminology. [1]
b
A student claims that anaphase is the most critical stage for ensuring each daughter cell receives an identical set of chromosomes. Using evidence from the events of anaphase and telophase, evaluate this claim. [1]
Solutions
3QuestionCell Cycle and MitosisAssessment Practice
2 marks~3 minCriterion D
Certain chemotherapy drugs work by blocking cell cycle checkpoints, preventing cells from completing division and triggering apoptosis. Oncologists use this mechanism to target tumour cells, which divide uncontrollably.
Explain why these drugs also damage healthy tissues such as hair follicles and the digestive tract lining, and outline one consequence of this for the patient. [2]
Explain why these drugs also damage healthy tissues such as hair follicles and the digestive tract lining, and outline one consequence of this for the patient. [2]
Solutions
4QuestionCell Cycle and MitosisAssessment Practice
2 marks~3 minCriterion A
The diagram below shows a cell in which chromosomes are maximally condensed and aligned along the equatorial plane, with spindle fibres visible extending from both poles.
a
Identify the stage of mitosis shown in the diagram. [1]
b
Explain why correct chromosome alignment at this stage is critical before the cell proceeds to the next stage of mitosis. [1]
Solutions
5QuestionCell Cycle and MitosisAssessment Practice
5 marks~8 minCriterion C
A researcher investigates the role of p53 in the cell cycle. Human cells are treated with a drug that inhibits p53 activity. The percentage of cells in each phase is recorded over 24 hours. In untreated cells, G1 remains at ~60%, S phase at ~30%, and G2/M at ~10%. In p53-inhibited cells, G1 drops from 60% to 20% over 12 hours, S phase rises from 30% to 70%, and G2/M remains at ~10%.
a
State the role of p53 at the G1/S checkpoint. [1]
b
Explain what the change in G1 and S phase percentages indicates about cell behaviour when p53 is inhibited. [2]
c
Evaluate the hypothesis: "p53 is essential for preventing cells from entering S phase." In your answer, use the data and identify one limitation of this conclusion. [2]
Solutions
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